at the age of 76. Comments on the Klinefelter syndrome This article contains too many or too-lengthy quotations for an encyclopedic entry. Please help improve the article by editing it to take facts from excessively quoted material and rewrite them as sourced original prose. Consider transferring direct quotations to Wikiquote. (August 2013) Klinefelter described his findings as follows: I first worked under Dr. Howard Means, measuring oxygen consumption of adrenal gland slices in the Warburg apparatus, but I was so unsuccessful at it, breaking most of the apparatus, that in September, I asked Dr. Means if I might work with Dr. Fuller Albright, since I primarily wanted to learn some clinical endocrinology. Dr. Albright was the most outstanding clinical endocrinologist in the world, and Dr. Means readily agreed. Albright's Saturday morning clinics were famous throughout the Massachusetts General Hospital. At the first one I attended, I saw a tall black boy named George Bland who had gynecomastia and very small testes (1.0–1.5 cm in length). When I asked Dr. Albright what this was all about, he said he did not know but that he would be happy for me to work on it. During the rest of the year, we found 8 other patients with this same condition and reported the series at the endocrine meetings in 1942. Dr. Albright was charitable enough to let me put my name first on the paper that was published later in 1942 in the Journal of Clinical Endocrinology. The title, “A Syndrome Characterized by Gynecomastia, Aspermatogenesis without Aleydigism, and Increased Excretion of Follicle-Stimulating Hormone,†was so long that the syndrome came to be known by my name, though it was really just another of Dr. Albright's diseases. Albright had more ideas in a day than most people have in a lifetime, and it was a great pleasure and privilege to work with him. Not only did he have great ideas and theories, but if someone came up with a fact that blasted his current theory, he soon had another one! He described the patients: These patients tend to be tall, with normal secondary sex characteristics; most have normal sexual function. ... these patients often have an entirely normal appearance save for their small testes, and I am sure many escape detection because the testes are often not examined in a general physical examination. (Several have) gynecomastia... He also described that a testicular biopsy shows "the atrophy and hyalinization of the seminiferous tubules with preservation of the Leydig or interstitial cells." Klinefelter comments on gynecomastia: A few years after the syndrome was described, Heller and Nelson reported that the gynecomastia was not a necessary part of the syndrome, though it occurred in about 75% of the patients. The hallmarks of the syndrome, therefore, are small testes, sterility, and increased excretion of follicle-stimulating hormone. On the later discovery of the extra X chromosome: Fourteen years after the original description of the
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
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Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
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Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs
Audrie Farel Hair Color, Body Shape, Family Members, Father, Mother, Brother, Sister, Marriage and Affairs.
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